Essential Gene Regulation in Multi-Drug Resistant Golden Staph: A New Path Towards Control

Grant number: 1145075 | Funding period: 2018 - 2021

Completed

Abstract

New antibiotics effective against Golden Staph are urgently needed. This project will investigate a new approach to weaken Golden Staph defences with the potential to make existing antibiotics more effective at killing these bacteria.

Related publications (3)

The two-component system WalKR provides an essential link between cell wall homeostasis and DNA replication in Staphylococcus aureus

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2023-12-01

Among the 16 two-component -y-tem- in the opportuni-tic human pathogen Staphylococcus aureus, only WalKR i- e-ential. Like the ort..

From cloning to mutant in 5 days: rapid allelic exchange in Staphylococcus aureus

IR Monk, TP Stinear

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In the last 10 years, the barriers preventing the uptake of foreign DNA by clinical Staphylococcus aureus isolates have been ident..

Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus

IR Monk, N Shaikh, SL Begg, M Gajdiss, LKR Sharkey, JYH Lee, SJ Pidot, T Seemann, M Kuiper, B Winnen, R Hvorup, BM Collins, G Bierbaum, SR Udagedara, JR Morey, N Pulyani, BP Howden, MJ Maher, CA McDevitt, GF King

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WalKR (YycFG) is the only essential two-component regulator in the human pathogen Staphylococcus aureus. WalKR regulates peptidogl..

University of Melbourne Researchers